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Human Pharmacogenomics SNP Detection Kit

Human Pharmacogenomics SNP Detection Kit

Mass Spectrometry

Only for scientific research use in China


It is reported that the side effects of drug reactions are the major cause of global death,ranking at fourth to sixth. In China, there are 2.5 million people who were hospitalized because of adverse drug reactions per year, 200,000 people died of adverse drug reactions per year. In the United States, 2 million people who were hospitalized because of adverse drug reactions per year, more than 100,000 people died of adverse drug reactions per year. The diversities of drug metabolicenzymes and pharmacological target genotypes can bring about individual differences in drug responsiveness (including drug efficacy and adverse drug reaction) through influencing the concentration of the drug invivo, and the sensitivity of the target tissue to the drug. This kit detects the SNP sites of 23 pharmacogenomics related genes, which can guide the clinical assessment for selecting appropriate drugs and dosage for specific patients, for achieving personalized medication, improving the effectiveness and safety of drug treatment and preventing the occurrance of serious adverse drug reactions.


Detectin Items


23 Genes68 Loci

Applicable

for 10 hospital

departments

Indications for more than 100 drugs

VKORC1, UGT1A1,

HLA - A,HLA - B,

TPMT, NAT1, NAT2,

G6PD,F5, F2,

CYP2D6, DPYD

and so on

VKORC1*6, UGT1A1*6,

HLA - A *3101,

HLAB*1502,

TPMT*2,TPMT*3B,

TPMT*4A,NAT1*14,

NAT1*17,NAT2*5,

Leiden,G20210A,

CYP2D6*3,

DPYD*10-V995F

and so on

Stratagene

Mx3000pTM,

ABI7500 etc.

α、β-receptorblocker: Carvedilol,

( Carvedilol Tablet)

hypotensor : Benazepril,

(Benazepril Hydrochloride Tablets)

antineoplastic drugs: Irinotecan

(Irinotecan Hydrochloride Injection),

cyclophosphamide

(Adenosine Cyclphosphate for 

Injection ,Compound CyclohosphamideTablets),

Adriamycin(Doxorubicin Hydrochloride forInjection)

and so on



Indications for pharmacogenomics SNP detection (Partial)



Pathological

Departments

GeneGenotypeDrugsPhenotype

Clinical

Significance
SuggestionsSignal

Department of 

Cardiovascular

UGT1A1*6GG

α,β-receptor blocker:

Carvedilol

(Carvedilol Tablet)

normal 

metabolizers

normal

response

normal

medication


    

MTHFR-C677TGGlipid-lowering drugs: 

Simvastatin ,

pravastatin

normal 

metabolizers

normal

response

normal

medication

    
APOEE4/E4

lipid-lowering drugs: 

Simvastatin ,

pravastatin

Poor 

metabolizers

less sensitive

to drugs

increase the 

dosage

      
CYP2D6*1/*2

normal 

metabolizers

normal

response

normal

medication

     




Department of Oncology
UGT1A1*6GG

(Irinotecan

 Hydrochloride Injection)

normal

metabolizers


normal 

response

normal

medication

     
PMP*3CTT

antineoplasticdrugs: 

Cisplatin( Cisplatin for

Injection), 

Cyclophosphamide

( Cyclophosphamide for 

Injection, CompoundCyclophosphamide Tablets)

normal

metabolizers

normal 

response

normal

medication

    


     

SLCO1B1*5TC 

(Irinotecan Hydrochloride

Injection),

Intermediate

metabolizers

May have an 

increased risk 

of leucopenia

Careful

medication

  

     !

CYP2B6*5CC

normal

metabolizers

normal 

response

normal

medication

     √


Performance Parameter

Product Name

Core Technology

Product Specification

Matched Instrument

Sample Types

Human

Pharmacogenomics

SNP Detection Kit

RingCap®

16 Tests/Kit or

32 Tests/Kit

Ion torrent ,

Illumina

peripheral

blood



Detection Significance 


 Direct clinical selection of appropriate drugs and dosage for specific patients.


●  Improve the effectiveness and safety of drug treatment and prevent the occurrence of serious adverse drug reactions.





Technical Highlights


Easy operation: Mass spectrometry, coupled with end point PCR, enables highly multiplexed reactions under universal cycling conditions. The instrument can finish desalting and sampling automatically.


Rapid Detection: With easy, clear bioinformatics and multiplexed detection, the data processing will be simplified, therefore, the detection time will be reduced. It takes only 1 day for results,just need little manual time.


Comprehensive Inspection: This kit can detect 23 target genes, 68 loci in one time, and it can make a comprehensive guidance for specific patients to select the appropriate drug and dosage, for personalized treatment.




Detection Process