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Human Chemotherapy Related Gene SPN Detection Kit

Human Chemotherapy Related Gene SPN Detection Kit

Next Generation Sequencing

Only for scientific research use in China



Chemotherapy and Personalized Therapy 

Chemotherapeutic drug susually act on rapidly dividing cells, inhibit the synthesis and replication of cell DNA, the form of microtubules, or the activity of metabolism enzymes. Clinical results have showed that only about 30% of patients can be benefited  from a chemotherapy regimen. Different individuals carry different genes correlated with chemotherapeutic drug responsiveness., therefore the patients' sensitivity and tolerance to specific drugs, and reactions to the toxicity of the drug itself are different.


 



Clinical Significance

Recently, lots of studies have showed that every chemotherapeutic drug has related targets which can be used for assessing the drug effect. Through the detection of the related gene status, the patient's drug sensitivity/ resistance can be evaluated. The detection results can be used to predict  the chemotherapy effect and guide the drug selection.



Detecion Items



Detecting GenesThe most common chemotherapeutic drugs 


DPYD,UGT1A1,MTHFR,ERCC1,

UMPS,CDA,DYNC2H1,DHFR,

GGH,GSTP1,CYP2B6,SLC22A16,

TP53,XRCC1,C8orf34,ABCC4,

MTR,CBR3,CYP2D6,ABCB1,

ABCC2,SOD2,XPC,SLC19A1,

FOLR3,FCGR3A



 platinum drugs,fluorouracil , leukovorum,

 gemcitabine,docetaxel,vinorelbine,Cytoxan,

 pharmorubici,paclitaxel,Irinotecan,pemetrexed,

 tegafur,anthracycline,tamoxifen,capecitabine,

 etopoplatinglycoside、methopterin



Performance Parameter



Core

Technology

Products

Specification

Matched

Instrument

Sample Requirements
Sample TypeQuantity

Preservation

Condition

RingCap ®

16 tests/kit or

 32 tests/kit

Ion torrent

PGM/S5

illumina

misq/miniseq

peripheral

blood

Use special 

anticoagulant tube

 to collect blood.

4℃




Advantages andCharacteristics


Easy operation: With independent patented RingCap ® technology, library construction can be done in two steps. 


Rapid Detection:Library construction takes only 3.5 hours, only 2 working days from sample  to report.


Accurate and Reliable: The target fragment was amplified by specific primer, and this kit is applicable to paraffin tissue and peripheral blood samples.




Detection Process