Human Oncology Multi-Gene Mutations Detection Kit
Next Generation Sequencing
CE-IVD Certificate no.：No.MDD-SZ-XW-160321
For scientific research use in China
Gene Mutation and Tumor
Tumor is the neoplasm of normal tissue, of which cancer is malignant neoplasm driven by various of tumorigenesis factors. Gene mutations caused by environment and heredity (including point mutation, deletion, insertion, copy number increase, gene fusion and so on) may lead to the division and growth of normal cells out of control and finally induce the formation of tumors.
Targeted drugs are able to target the pathologic molecules in cancer cells caused by specific gene mutations, which will maximize the drug efficacy and minimize the side effects. Therefore, the detection of the patient's gene status can contribute the clinicians to select suitable target drugs.
The initiation of the tumor is usually caused by activation proto-oncogenes or inactivation suppressor oncogenes. Studies had shown that 87% of Asian patients with lung adenocarcinoma have carried known kinds of driver genes mutations, 81% of which had clear target inhibitors, thus, 66% of patients can be treated with personalized target treatments.
Seo JS, et al. Genome Res 2012;22:2109-2119.
• Assist clinicians to select targeted drugs for patients.
• Predict efficacy and resistance of targeted drugs.
|No.||Name||Gene Type||Covered Exons||Number of Mutations|
16 tests/kit or
Advantages and Characteristics
Easy Operation: With independent patented RingCap® technology, library construction can be done in only two steps.
Rapid Detection: Library construction takes only 3.5 hours, only 2 working days from sample processing to reporting.
High Sensitivity:20000x sequencing depth. Up to 0.1% of sensitivity. Achieving the drug resistance monitoring for the liquid biopsy samples.
Comprehensive Detection: Detecting 13 mutated genes, covering 482 existing targeted drug-related COSMIC loci in one time. Comprehensive analysis the genetic information of non-small cell lung cancer andcolorectal cancer. To guide the use of targeted drugs which is recommended by the domestic and foreign authoritative institutions.