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Human Pharmacogenomics SNP Detection Kit

Human Pharmacogenomics SNP Detection Kit

Next Generation Sequencing

CE-IVD Certificate no.No.MDD-SZ-XWA1-180523

Only for scientific research use in China



It is reported that adverse drug reactions accounted for the fourth to sixth major cause of global death.In China, there are 2.5 million people who were hospitalized because of adverse drug reactions per year,  200,000 people died of adverse drug reactions per year.In the United States,  2 million people who were hospitalized because of adverse drug reactions per year,  more than 100,000 people died of adverse drug reactions per year.  


Change in drug metabolicenzymes and pharmacological target genes characteristics can bring about individual differences in drug responsiveness (including drug efficacy and adverse drug reaction) through influencing the concentration of the drug invivo , and the sensitivity of the target tissue to the drug. This kit detects the SNP mutations of 22 pharmacogenomics related genes, which can guide the clinical selection of appropriate drugs and dosage for specific patients, to achieve individualized medication, so as to improve the effectiveness and safety of drug treatment and prevent serious adverse drug reactions occur.

 

Detected sites of the kit


No.Gene NameGenotypers IDNo.Gene NameGenotypers ID
1APOEAPOE-E2rs741229CYP2C9CYP2C9*2rs1799853
2APOE-E4rs42935830CYP2C9*11rs28371685
3COMTCOMTrs468031CYP3A5CYP3A5*3rs776746
4CYP1A2CYP1A2*1Crs206951432CYP3A5*6rs10264272
5CYP1A2*1Frs76255133CYP3A5*7rs41303343
6CYP1A2*1Krs206952634DPYDDPYD*10rs1801268
7CYP2B6CYP2B6*18rs2839949935
DPYD*2Ars3918290
8CYP2B6*5rs321137136DPYD*8rs1801266
9CYP2C19CYP2C19*10rs641343837DPYD*9Ars1801265
10CYP2C19*17rs1224856038F2F2rs1799963
11CYP2C19*2rs424428539F5F5rs6025
12CYP2C19*3rs498689340
G6PDG6PD*A_202Ars1050828
13CYP2C19*4rs2839950441G6PD*A376Grs1050829
14CYP2C19*5rs5633701342G6PD*A542Grs5030872
15CYP2C19*6rs7255226743G6PD*G680Trs137852328
16CYP2C19*7rs7255818644G6PD*T968Crs76723693
17CYP2D6CYP2D6*12rs503086245HLA-AHLA-A*3101rs1061235
18CYP2D6*17rs2837170646HLA-BHLA-B*5701rs2395029
19CYP2D6*2rs1694747IFNL3IFNL3rs12979860
20CYP2D6*29rs5942138848MTHFRMTHFR-1298Crs1801131
21CYP2D6*3Ars3574268649MTHFR-677Trs1801133
22CYP2D6*41rs2837172550NAT2NAT2*14rs1801279
23CYP2D6*8rs503086551NAT2*5rs1801280
24TPMTTPMT*2rs180046252NAT2*6rs1799930
25TPMT*3Brs180046053NAT2*7rs1799931
26TPMT*3Crs114234554SLCO1B1SLCO1B1*5rs4149056
27TPMT*4rs180058455UGT1A1UGT1A1*6
28VKORC1VKORC1*2rs9923231——————




Clinical Significance of Detecting


• Direct clinical selection of appropriate drugs and dosage for specific patients.

• Improve the effectiveness and safety of drug treatment and prevent the occurrence of serious adverse drug reactions.


Performance Parameter


Core

Technology

Product 

Specification

Matched 

Instrument

Sample requirements

Sample Types

Quantity

Preservation Condition

RingCap®

16 Tests/Kit or

32 Tests/Kit

Ion torrent PGM/S5,

MiSeq/miniseq

peripheral

blood

10mL

2~6℃



Detection Process




Advantages and Characteristics


Easy operation: With independent patented RingCap™ technology, library construction can be done in two steps.


Rapid Detection: Library construction takes only 3.5 hours, only 2 working days from sample to report.


Comprehensive Inspection:This kit can detect 22 target genes, 85 loci in one time, and it can make a comprehensive guidance for specific patients to select the appropriate drug and dose, so as to achieve individualized medication.