Current location: Home > PRODUCTS > Next Generation Sequencing Series Products

PRODUCTS

Human Pharmacogenomics SNP Detection Kit

Human Pharmacogenomics SNP Detection Kit

Next Generation Sequencing

CE-IVD Certificate no.No.MDD-SZ-XWA1-180523

Only for scientific research use in China



It is reported that the side effects of drug reactions are the major cause of global death, ranking at the fourth to sixth. In China, there are 2.5 million people who were hospitalized because of adverse drug reactions per year, 200,000 people died of adverse drug reactions per year. In the United States, 2 million people who were hospitalized because of adverse drug reactions per year, more than 100,000 people died of adverse drug reactions per year.


The diversities of drug metabolic enzymes and pharmacological target genotypes can bring about individual differences in drug responsiveness (including drug efficacy and adverse drug reaction) through influencing the concentration of the drug in vivo, and the sensitivity of the target tissue to the drug. This kit detects 55 SNP sites of 21 pharmacogenomics related genes, which can guide the clinical assessment for selecting appropriate drugs and dosage for individaul patients, for achieving personalized medication, improving the effectiveness and safety of drug treatment and preventing the occurrence of serious adverse drug reactions.


 

Detection Items


21 Genes55 Loci

Applicable for 10 hospital departments

Indications for more than 100 drugs

VKORC1, UGT1A1,

H L A - A,H L A - B,

TPMT, NAT2,G6PD,

F 5, F 2,CYP2D6,

DPYD ,APOE,COMT,

CYP1A2,CYP2B6,

CYP2C19,CYP2C9,

CYP3A5 etc.

VKORC1*6, UGT1A1*6,

H L A - A * 3 1 0 1,

HLAB*1502,TPMT*2,

TPMT*3B,TPMT*4A,

N A T 2*5,Leiden,

G20210A, CYP2D6*3,

DPYD*10-V995F etc.

Department of

cardiovascular,

Department of

neurology,

Department of

oncolog

α、β-receptor blocker: Carvedilol,( Carvedilol Tablet)

hypotensor : Benazepril,

(Benazepril Hydrochloride Tablets)antineoplastic drugs: Irinotecan

(Irinotecan Hydrochloride Injection),cyclophosphamide

(Adenosine Cyclphosphate for Injection ,Compound Cyclohosphamide Tablets),

Adriamycin(Doxorubicin Hydrochloride for Injection)and so on



Indications for pharmacogenomics SNP detection (Partial)

Pathological

Departments

GeneGenotypeDrugsPhenotype

Clinical

Significance

SuggestionsSignal
Departmentof CardiovascularUGT1A1*6
GG

α,β-receptor blocker:

Carvedilol

(Carvedilol Tablet)

normal 

metabolizers

normal

response

normal

medication

MTHFR-C677TGG

hypotensor :Benazepril

(Benazepril Hydrochloride Tablets)

normal 

metabolizers

normal

response

normal

medication

APOEE4/E4

lipid-lowering drugs: 

Simvastatin ,

pravastatin

Poor 

metabolizers

less sensitive

to drugs

increase the 

dosage

CYP2D6*1/*2

antiarrhythmic drugs.

Flecainide

normal 

metabolizers

normal

response

normal

medication


Departmentof 

Oncology

UGT1A1*6GG(Irinotecan HydrochlorideInjection)

normal

metabolizers

normal 

response

normal

medication

PMP*3CTT antineoplasticdrugs: Cisplatin( Cisplatin forInjection), Cyclophosphamide( Cyclophosphamide for Injection, CompoundCyclophosphamide Tablets)

normal

metabolizers

normal 

response

normal

medication

SLCO1B1*5TC (Irinotecan HydrochlorideInjection),

Intermediate

metabolizers

Mayhave an increased risk of 

leucopenia

Careful

medication

CYP2B6*5
CCantineoplasticdrugs: Cyclophosphamide(Cyclophosphamide for Injection, Compound Cyclophosphamide Tablets)

normal

metabolizers

normal 

response

normal

medication



Performance Parameter


Product Name

Core

Technology

Product

Specification

Matched

Instrument

Sample

Types

Human

Pharmacogenomics

SNP Detection Kit

RingCap®

16 Tests/Kit or

32 Tests/Kit

Ion torrent ,

Illumina

peripheral

blood



Detection Significance 


• Direct clinical selection of appropriate drugs and dosage for specific patients.

• Improve the effectiveness and safety of drug treatment and prevent the occurrence of serious adverse drug reactions.


Technical Highlights


Easy operation: With independent patented RingCap technology, library construction can be done in two steps. 


Rapid Detection: Library construction takes only 3.5 hours.Only 5 working days from sample processing to reporting.


Comprehensive Inspection: This kit can detect 21 target genes, 55 loci in one time, and it can make a comprehensive guidance for specific patients to select the appropriate drug and dosage, for personalizedtreatment.



Detection Process