Human B-raf Gene Mutation Detection Kit
Real Time PCR
For scientific research use in China
CE-IVD Certificate no.：No.MDD-SZ-XW-160321
Individualized targeted therapy new methods of molecular analysis, :Using to help doctors and patients choose the most effective drugs, and to better control the disease progression according to the patient's genetic characteristics, thus to develop a suitable individualized therapy.
Targeted Drugs and BRAF Gene Mutation
Colorectal cancer patients with BRAF gene mutation will have worse response to the treatment of Cetuximab and Panitumumab. As a prognostic marker,BRAF gene mutation detection is important for the diagnosis and prognosis of colorectal cancer and thyroid cancer.Studies have shown that some patients with wild-type KRAS gene is also resistant to EGFR-targeted drugs, which is due to the gene mutation of downstream BRAF.
Gene detection of BRAF is extremely significant for patients in elevating EGFR -TKI drug resistance and choosing treatments, to avoid unnecessary treatment and Provide a direct guidance for treatments to BRAF mutation carriers .
Clinical Practice Guideline for colorectal cancer (NCCN) (2016 V2 Edition) suggest that the status of KRAS should be detected while using the targeted drugs such as Cetuximab and Panitumumab. If there is no mutation in KRAS, a further detection of BRAF gene status should be considered.
B-raf gene in
DNA samples of
Advantages and Characteristics
Accuracy and Reliability: Detection with closed tubes. Require no special treatment of the products.
High Sensitivity: Accurate detection of single copies of mutated DNA samples as little as10ng genome.
Easy operation: One-step operation. 90 minutes of the whole process.
Good Reproducibility: Can be performed in the general PCR Labs. Results with good reproducibility can be easily obtained without special training.
Advanced Technology: R&D based on independent patented PAP-ARMS technology.